CAS 13870-90-1 Kobamamid kukuni

1. Kirishkanalizatsiya

Kobamamid kukuni oktaedral kobalamin kompleksi bo'lgan 5-dimetilbenzimidazol-5-deoksiadenin nukleozid kobalamin deb ataladigan B12 vitaminining seriyali mahsulotlaridan biridir. Bu to'q qizil rangli kristalli va kristalli bo'lmagan kukun bo'lib, kuchli gigroskopiklikka ega va yorug'lik ostida oson parchalanadi. Bu xom ashyo dori bo'lgan va muhim tibbiy ahamiyatga ega bo'lgan vitamin B12 seriyali mahsulotlarning muhim xilma-xilligi.

Bu hujayralardagi nukleotidlar sintezi uchun muhim koenzim bo'lgan siyanokobalt B12 vitaminining analogidir, metil konversiyasi va foliy kislotasi metabolizmida ishtirok etadi, metil foliy kislotasini tetrahidrofol kislotasiga kamaytirishga yordam beradi va trikarboksilik kislota aylanishida ham ishtirok etadi, Sulfhidrilazani quruq faol holga keltira oladigan miyelin qobig'idagi lipoproteinlarning Chemicalbook shakllanishi uchun juda muhim bo'lib, shu bilan protein va yog 'almashinuvining keng spektrida ishtirok etadi. Ushbu mahsulot qizil qon hujayralarining rivojlanishi va kamolotini rag'batlantirishi mumkin, bu nerv qobig'ining orqa miya tolalarini to'liq shakllantirish va ovqat hazm qilish tizimining epitelial hujayralarining funktsiyasini saqlab turish uchun zarur omil hisoblanadi.

2.Funksiyalar

2.1 Cobamamide powder is used for diseases caused by vitamin B12 deficiency, such as anemia during pregnancy and malnutrition. It can also be used in the adjuvant treatment of nutritional diseases and leukopenia caused by radiation and drugs.

Vitamin B-12 concentrations in breast milk among 68 vitamin B-12–supplemented mothers was significantly higher than that of 73 women who were administered placebo when supplementation ended at 6 wk postpartum (Table 2). However, breast milk vitamin B-12 concentrations at 3 and 6 mo postpartum were not significantly different between the treatment groups.

2.2 Chemical research and tissue culture. Clinical drugs belong to vitamin B group, which participate in the synthesis of nucleic acid, choline, methionine and the metabolism of fat and sugar in vivo. They are used to treat various megaloblastic anemia, malnutrition anemia and other diseases.

3. Ilovalar

Kobamamid kukuni asosiy farmatsevtika sanoati uchun ishlatiladi.

4. Texnik xususiyatlar

5. Oqim sxemasi

6. Sinov usuli

TAHLIB

• PROCEDURE

Yechim A: metanol

B yechim: 950 ml suvda 6,8 g bir asosli kaliy fosfat eritiladi. 10 foizli fosfor kislotasi bilan pH 3,2 ga sozlang.

Dilute with water to 1000 mL. Pass this solution through a ¦lter of 0.2-µm pore size.

Mobil bosqich: 1-jadvalga qarang.

Suyultiruvchi: metanol va suv (1:3)

NOTE—Use low-actinic glassware, and protect the following solutions from exposure to light.

Tizimga mos keladigan yechim: 0, USP Cobamamid RS, USP Cyanocobalamin (Crystalline) RS, USP Hydroxocobalamin har biri 0,05 mg/ml

Suyultirgichdagi xlorid RS va USP metilkobalamin RS

Standart yechim: USP Cobamamid RS ning tegishli qismi xonaning nisbiy namligi va himoyalangan sharoitda muvozanatlashishiga ruxsat bering.

yorug'likdan, uning og'irligi o'zgarmasligicha. Muvozanat vaqti nisbiy xonaga qarab 60 minutgacha yoki undan ko'p bo'lishi mumkin

namlik. Suyultiruvchida 1 mg/ml eritma tayyorlash uchun muvozanatlangan materialdan foydalaning. Bir vaqtning o'zida suv tarkibini aniqlang

muvozanatlashtirilgan namunani oling va tahlilni tuzatish uchun foydalaning.

Yechim namunasi: USP Cobamamid RS ni Kobamamid bilan almashtirish bundan mustasno, standart eritmada ko'rsatilgandek tayyorlang.

Xromatografik tizim

(See Chromatography 〈621〉, System Suitability.)

Rejim: LC

Detektor: UV 260 nm

Column: 4.6-mm 10-cm; 2.6-µm packing L1

Ustun harorati: 40 daraja

Oqim tezligi: 1,2 ml/min

Injection volume: 5 µL

Tizimning mosligi

Namunalar: tizimga moslik yechimi va standart yechim

NOTE—The relative retention times for cobamamide, hydroxocobalamin, cyanocobalamin, and methylcobalamin are 1.00, 0.15, 0.40,

va 1.47, mos ravishda, Tizimga muvofiqlik yechimi.

Muvofiqlik talablari

Column e¨ciency: NLT 22,000 theoretical plates for the cobamamide peak, Standard solution

Qoldiq omil: NMT 2.0 kobamamid cho'qqisi uchun, Standart eritma

Tahlil

Namunalar: standart eritma va namunali eritma

Kobamamidning olingan qismidagi kobamamid (C72H100CoN18O17P) foizini hisoblang:

Result = (rU/rS)  (CS/CU)  100

rU= peak response of cobamamide from the Sample solution

rS=standart eritmadan kobamamidning eng yuqori javobi

Standart eritmadagi USP Cobamamid RS ning CS=kontsentratsiyasi (mg/ml)

Namuna eritmasi=kobamamid kontsentratsiyasi (mg/ml)

Acceptance criteria: 96.0 percent –102.0 percent on the anhydrous basis

7. Barqarorlik va xavfsizlik

Biz ushbu mahsulot haqida koʻplab barqarorlik va xavfsizlik tadqiqotlarini oʻtkazdik, tezlashtirilgan va uzoq muddatli barqarorlik maʼlumotlariga koʻra, u barqaror xususiyatlarga ega; hayvonlarning klinik tadqiqotiga ko'ra, u xavfsiz natijalarni ko'rsatadi.

8. Sertifikat

9. Ko'rgazma

10. Bizning mijozlarimiz

11.Customers'Review

Issiq teglar: cas 13870-90-1 kobamamid kukuni, ishlab chiqaruvchilar, etkazib beruvchilar, zavod, ulgurji, sotib olish, narx, eng yaxshi, ommaviy, sotuvda